Neuroleukin: A Lymphokine Product of Lectin-Stimulated T Cells

• DOI: 10.1126/science.3020690
• Publication Date: 2006-10-05T20:28:52Z
• Authors: Mark E. Gurney; Brian R. Apatoff; Gregory T. Spear; Mark J. Baumel; Jack P. Antel; Margaret Brown Bania; Anthony T. Reder
• Keywords: B-Lymphocytes; Immunity, Cellular; Lymphokines; 0303 health sciences; Leukemia; Lymphoma; T-Lymphocytes; Glucose-6-Phosphate Isomerase; Immunoglobulins; Deltaretrovirus; Cell Line; 3. Good health; Mice; 03 medical and health sciences; Pokeweed Mitogens; Bone Marrow; Lectins; Sequence Homology, Nucleic Acid; Animals; Humans; Growth Substances; Cells, Cultured

Neuroleukin is a lymphokine product of lectin-stimulated T cells that induces immunoglobulin secretion by cultured human peripheral blood mononuclear cells. acts early in the vitro response leads to formation antibody-secreting cells, but continued production differentiated neuroleukin-independent. Although factor not directly mitogenic, cellular proliferation late component neuroleukin. does have B-cell growth (BCGF) or differentiation (BCDF) activity defined assays. Neuroleukin-evoked induction both monocyte- and cell-dependent.