Localization of an Arg-Gly-Asp Recognition Site Within an Integrin Adhesion Receptor

• DOI: 10.1126/science.3262922
• Publication Date: 2006-10-05T21:21:15Z
• Authors: Stanley E. D'Souza; Mark H. Ginsberg; Timothy A. Burke; Stephen C.-T. Lam; Edward F. Plow
• Keywords: Sequence (biology)

Many adhesive interactions are mediated by Arg-Gly-Asp (RGD) sequences within proteins. Such RGD frequently recognized structurally related heterodimers that members of the integrin family adhesion receptors. A region was found in platelet receptor, gpIIb/IIIa, to which an peptide becomes chemically cross-linked. This corresponds residues 109 171 gpIIIa. segment is conserved among β subunits integrins (76 percent identity sequence), indicating it may play a role functions this