Genetic Selection of a Plasmodium -Refractory Strain of the Malaria Vector Anopheles gambiae

• DOI: 10.1126/science.3532325
• Publication Date: 2006-10-05T20:28:52Z
• Authors: Frank H. Collins; Richard K. Sakai; Kenneth D. Vernick; Susan Paskewitz; Douglas C. Seeley; Louis H. Miller; William E. Collins; Carlos C. Campbell; Robert W. Gwadz
• Keywords: Anopheles gambiae; Blood meal; Plasmodium (life cycle); Avian Malaria

The anopheline mosquito is the target in most malaria control programs, primarily through use of residual insecticides. A was studied that refractory to species a genetically controlled mechanism. strain Anopheles gambiae, which selected for complete refractoriness simian parasite Plasmodium cynomolgi, also has varying degrees other examined, including human parasites P. falciparum, ovale, and vivax this principal African vector. Furthermore, extends subhuman primate malarias, rodent malaria, avian malaria. Refractoriness manifested by encapsulation ookinete after it completes its passage midgut, approximately 16 24 hours ingestion an infective blood meal. Fully encapsulated ookinetes show no abnormalities organelles, suggesting due enhanced ability host recognize living rather than passive dead or dying parasite. Production fully susceptible strains achieved short series selective breeding steps. This result indicates relatively simple genetic basis refractoriness. In addition value these may serve general studies insect immune mechanisms, finding encourages consideration manipulation natural vector populations as strategy.