Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

• DOI: 10.1126/science.3933111
• Publication Date: 2006-10-05T19:42:50Z
• Authors: Barry J. Sugarman; Bharat B. Aggarwal; Philip E. Hass; Irene S. Figari; Michael A. Palladino; H. Michael Shepard
• Keywords: Alpha (finance)

Modulation of the growth human and murine cell lines in vitro by recombinant tumor necrosis factor-alpha (rTNF-alpha) interferon-gamma (rIFN-gamma) was investigated. rTNF-alpha had cytostatic or cytolytic effects on only some lines. When administered together with rIFN-gamma, showed enhanced antiproliferative a subset tested. In contrast to its sensitive cells, augmented normal diploid fibroblasts. Variations proliferative response induced were apparently not due differences either number binding sites per their affinity for rTNF-alpha. These observations indicate that are limited but rather this protein may have broad spectrum activities vivo.