Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors

• DOI: 10.1126/science.432641
• Publication Date: 2006-10-05T16:39:42Z
• Authors: J. N. Weinstein; R. L. Magin; M. B. Yatvin; D. S. Zaharko
• Keywords: Dihydrofolate reductase

Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to murine tumors heated 42 C unheated control tumors. Most of the accumulated drug appeared be intracellular and bound dihydrofolate reductase, enzyme blocked by in its role an antineoplastic agent.