Transmission of Simian Acquired Immunodeficiency Syndrome (SAIDS) with Blood or Filtered Plasma

Acquired Immunodeficiency Syndrome 0303 health sciences Cytomegalovirus Immunoglobulins Lymphocyte Activation Macaca mulatta 3. Good health Lymphatic System Plasma 03 medical and health sciences Blood Retroviridae Viruses Animals Filtration
DOI: 10.1126/science.6318315 Publication Date: 2006-10-05T19:41:59Z
ABSTRACT
Simian acquired immunodeficiency syndrome (SAIDS), a disease clinically and pathologically similar to acquired immunodeficiency syndrome in humans, was transmitted from diseased rhesus monkeys ( Macaca mulatta ) to normal monkeys by inoculation with heparinized whole blood or plasma that had been passed through filters of 0.45 micrometer pore size. This suggests that the causative agent is small and most probably a virus. No viruses, however, were isolated by standard cell culture techniques from the blood or filtered plasma which caused SAIDS. Both cellular and humoral immunity were markedly depressed in animals with advanced SAIDS.
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