Transmission of Simian Acquired Immunodeficiency Syndrome (SAIDS) with Blood or Filtered Plasma
Acquired Immunodeficiency Syndrome
0303 health sciences
Cytomegalovirus
Immunoglobulins
Lymphocyte Activation
Macaca mulatta
3. Good health
Lymphatic System
Plasma
03 medical and health sciences
Blood
Retroviridae
Viruses
Animals
Filtration
DOI:
10.1126/science.6318315
Publication Date:
2006-10-05T19:41:59Z
AUTHORS (13)
ABSTRACT
Simian acquired immunodeficiency syndrome (SAIDS), a disease clinically and pathologically similar to acquired immunodeficiency syndrome in humans, was transmitted from diseased rhesus monkeys (
Macaca mulatta
) to normal monkeys by inoculation with heparinized whole blood or plasma that had been passed through filters of 0.45 micrometer pore size. This suggests that the causative agent is small and most probably a virus. No viruses, however, were isolated by standard cell culture techniques from the blood or filtered plasma which caused SAIDS. Both cellular and humoral immunity were markedly depressed in animals with advanced SAIDS.
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