A Glycolipid Antigen Associated with Burkitt Lymphoma Defined by a Monoclonal Antibody

• DOI: 10.1126/science.6836295
• Publication Date: 2006-10-05T14:37:18Z
• Authors: E. Nudelman; R. Kannagi; S. Hakomori; M. Parsons; M. Lipinski; J. Wiels; M. Fellous; T. Tursz
• Keywords: Globotriaosylceramide; Burkitt's lymphoma

The antigen defined by a rat monoclonal antibody directed to Burkitt lymphoma cell line was identified as globotriaosylceramide [Galα(1 → 4)-Galβ(1 4)-Glcβ(1 1)-ceramide]. demonstrated strict steric specificity since it did not react with globoisotriaosylceramide 3)-Galβ(1 1)-ceramide], the positional isomer of associated lymphoma. Chemical analysis various lines revealed that cells contained more than 100 times much glycolipid found in other human and leukemia lines.