Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein

• DOI: 10.1126/science.7527157
• Publication Date: 2006-10-06T00:01:25Z
• Authors: D Jackson; O. Volpert; N Bouck; D. Linzer
• Keywords: 0303 health sciences; Neovascularization, Pathologic; Placenta; Pregnancy Proteins; Prolactin; Rats; Cornea; 03 medical and health sciences; Cell Movement; Pregnancy; Culture Techniques; Animals; Intercellular Signaling Peptides and Proteins; Cattle; Female; Fibroblast Growth Factor 2; Endothelium, Vascular; Growth Substances; Glycoproteins

In many mammalian species, the placenta is site of synthesis proteins in prolactin and growth hormone family. Analysis two such proteins, proliferin (PLF) proliferin-related protein (PRP), revealed that they are potent regulators angiogenesis; PLF stimulated PRP inhibited endothelial cell migration culture neovascularization vivo. The mouse secretes an angiogenic activity during middle pregnancy corresponds primarily to PLF, but later gestation releases a factor inhibits angiogenesis, which was identified as PRP. Incubation placental tissue with led specific binding this capillary cells. Thus may regulate initiation then cessation neovascularization.