A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

• DOI: 10.1126/science.7618087
• Publication Date: 2006-10-27T18:19:42Z
• Authors: Gina M. Doody; Louis B. Justement; Catherine C. Deli...; R. James Matthews; Jiejian Lin; Matthew L. Thomas; Douglas T. Fearon
• Keywords: CD22

CD22 is a membrane immunoglobulin (mIg)-associated protein of B cells. tyrosine-phosphorylated when mIg ligated. Tyrosine-phosphorylated binds and activates SHP, tyrosine phosphatase known to negatively regulate signaling through mIg. Ligation prevent its coaggregation with lowers the threshold at which cell by factor 100. In secondary lymphoid organs, may be sequestered away from interactions counterreceptors on T Thus, molecular switch for SHP that bias anatomic sites rich in