A Receptor for the Malarial Parasite Plasmodium vivax : the Erythrocyte Chemokine Receptor

• DOI: 10.1126/science.7689250
• Publication Date: 2006-10-05T23:05:09Z
• Authors: Richard Horuk; Chetan E. Chitnis; Walter C. Darbonne; Timothy J. Colby; Anne Rybicki; Terence J. Hadley; Louis H. Miller
• Keywords: Plasmodium knowlesi; CC chemokine receptors; Chemokine receptor CCR5

Plasmodium vivax and P. falciparum are the major causes of human malaria, except in sub-Saharan Africa where people lack Duffy blood group antigen, erythrocyte receptor for . negative erythrocytes resistant to invasion by related monkey knowlesi Several lines evidence present study indicate that antigen is chemokines interleukin-8 (IL-8) melanoma growth stimulatory activity (MGSA). First, IL-8 binds minimally erythrocytes. Second, a monoclonal antibody blocked binding other positive Third, both MGSA parasite ligand , suggesting possibility blockade anti-malarial therapy.