Subsets of HLA-DR1 Molecules Defined by SEB and TSST-1 Binding

• DOI: 10.1126/science.7997881
• Publication Date: 2006-10-06T00:01:25Z
• Authors: Jacques Thibodeau; Isabelle Cloutier; Pascal M. Lavoie; Nathalie Labrecque; Walid Mourad; Theodore Jardetzky; Rafick-Pierre Sékaly
• Keywords: Superantigen; Toxic shock syndrome

Superantigens bind to major histocompatibility complex class II molecules on antigen-presenting cells and stimulate T cells. Staphylococcus aureus enterotoxin B (SEB) toxic shock syndrome toxin-1 (TSST-1) the same region of human lymphocyte antigen (HLA)-DR1 but do not compete with each other, which indicates that they different subsets DR1 molecules. Here, a mutation in peptide-binding groove disrupted SEB TSST-1 binding sites, suggests peptides can influence interaction bacterial toxins. In support this, expression molecule various cell types differentially affected these