Receptor and Ligand Domains for Invasion of Erythrocytes by Plasmodium falciparum

• DOI: 10.1126/science.8009226
• Publication Date: 2006-10-06T00:01:25Z
• Authors: B. K. L. Sim; C. E. Chitnis; K. Wasniowska; T. J. Hadley; L. H. Miller
• Keywords: Glycophorin

A 175-kilodalton erythrocyte binding protein, EBA-175, of the parasite Plasmodium falciparum mediates invasion erythrocytes. The receptor for EBA-175 is dependent on sialic acid. domain that binds erythrocytes was identified as region II with use truncated portions expressed COS cells. Region II, which contains a cysteine-rich motif, and native bind specifically to glycophorin A, but not B, membrane. Erythrocyte recognition requires both acid peptide backbone A. identification ligand domains may suggest rational designs blockade vaccines.