Gene for Familial Psoriasis Susceptibility Mapped to the Distal End of Human Chromosome 17q

• DOI: 10.1126/science.8178173
• Publication Date: 2006-10-06T00:01:25Z
• Authors: James Tomfohrde; Alan Silverman; Robert Barnes; Marcelo A. Fernan...; Melodie Young; Detra Lory; Laura Morris; Kirk D. Wuepper; Peter Stastny; Alan Menter; Anne Bowcock
• Keywords: Genetic Markers; Male; 0303 health sciences; Polymorphism, Genetic; Base Sequence; Genetic Linkage; Molecular Sequence Data; Chromosome Mapping; HLA-C Antigens; DNA, Satellite; Pedigree; 03 medical and health sciences; Haplotypes; Humans; Psoriasis; Female; Disease Susceptibility; Lod Score; Alleles; Software; Chromosomes, Human, Pair 17; DNA Primers

A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6 , two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus.