Alterations of a Zinc Finger-Encoding Gene, BCL-6 , in Diffuse Large-Cell Lymphoma

• DOI: 10.1126/science.8235596
• Publication Date: 2006-10-05T23:05:09Z
• Authors: Bihui H. Ye; Florigio Lista; Francesco Lo Coco; Daniel M. Knowles; Kenneth Offit; R. S. K. Chaganti; Riccardo Dalla-Fa...
• Keywords: Pathogenesis; Coding region; Zinc finger nuclease

The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6 , codes for a 79-kilodalton protein that homologous with zinc finger-transcription factors. In 33 percent (13 39) DLCL samples, but not other types lymphoid malignancies, truncated within its 5′ noncoding sequences, suggesting expression deregulated. Thus, may be proto-oncogene specifically involved