Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

• DOI: 10.1126/science.8266077
• Publication Date: 2006-10-05T23:05:09Z
• Authors: Masayuki Noguchi; Yoshiaki Nakamura; Sarah M. Russell; Steven F. Ziegler; Monica Tsang; Xiqing Cao; Warren J. Leonard
• Keywords: Common gamma chain

The interleukin-2 (IL-2) receptor gamma chain (IL-2R gamma) is an essential component of high- and intermediate-affinity IL-2 receptors. IL-2R was demonstrated to be a the IL-4 on basis chemical cross-linking data, ability augment binding affinity, requirement for in IL-4-mediated phosphorylation insulin substrate-1. observation that functional receptor, together with finding associates IL-7 begins elucidate why deficiency this common (gamma c) has profound effect lymphoid function development, as seen X-linked severe combined immunodeficiency.