Inhibition of Transcriptional Regulator Yin-Yang-1 by Association with c-Myc

• DOI: 10.1126/science.8266081
• Publication Date: 2006-10-05T23:05:09Z
• Authors: A. Shrivastava; S. Saleque; G. V. Kalpana; S. Artandi; S. P. Goff; K. Calame
• Keywords: YY1; Transcription; GATAD2B

Yin-Yang-1 (YY1) regulates the transcription of many genes, including oncogenes c- fos and myc . Depending on context, YY1 acts as a transcriptional repressor, activator, or initiator. The yeast two-hybrid system was used to screen human complementary DNA (cDNA) library for proteins that associate with YY1, cDNA isolated. Affinity chromatography confirmed associates c-Myc but not Max. In cotransfections, inhibits both repressor activator functions which suggests one way is by modulating activity YY1.