Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C

• DOI: 10.1126/science.aaa4029
• Publication Date: 2015-06-11T18:57:00Z
• Authors: Zhejian Ji; Haishan Gao; Hongtao Yu
• Keywords: Spindle checkpoint

How cells sense connected chromosomes Cells have a “checkpoint” that pauses cell division until all are properly arranged on the mitotic spindle to allow precise distribution of one copy each chromosome daughter cell. Hiruma et al. and Ji explain molecular mechanism by which they ready divide. The protein kinase MPS1 associates with complex at kinetochore chromosome. Its activity produces signals pause cycle. When becomes attached spindle, microtubules physically compete for binding same site where is bound. Thus, once attached, dissociates, inhibitory signal lost, allowed proceed. Science , this issue pp. 1264 1260