Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

• DOI: 10.1126/science.aad0616
• Publication Date: 2015-10-15T21:56:28Z
• Authors: Hye-Jung Kim; R. Anthony Barnitz; Taras Kreslavsky; Flavian D. Brown; Howell Moffett; Madeleine E. Lemieux; Yasemin Kaygusuz; Torsten Meissner; Tobias A. W. Hold...; Susan Chan; Philippe Kastner; W. Nicholas Haining; Harvey Cantor
• Keywords: Stimulus (psychology)

How T cells maintain their identity Although best known for pathogen-fighting prowess, lymphocytes also ensure that the immune response does not run amok. A subset of called regulatory (T regs ) performs this function by, example, making sure only attack pathogens and self. can exhibit plasticity in functions face an inflammatory stimulus. Kim et al. sought to identify molecules stable maintenance . Using genetically modified mice, they found both CD4 + CD8 require transcription factor Helios stably identity. Science , issue p. 334