Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

• DOI: 10.1126/science.aad3517
• Publication Date: 2016-03-10T19:36:06Z
• Authors: Paolo Zanoni; Sumeet A. Khetarpal; Daniel B. Larach; William F. Hancoc...; John S. Millar; Marina Cuchel; Stephanie DerOhan...; Anatol Kontush; Praveen Surendran; Danish Saleheen; Stella Trompet; J. Wouter Jukema; Anton De Craen; Panos Deloukas; Naveed Sattar; Ian Ford; Chris Packard; Abdullah al Shafi...; Dewan S. Alam; Emanuele Di Angel...; Goncalo Abecasis; Rajiv Chowdhury; Jeanette Erdmann; Børge G. Nordestg...; Sune F. Nielsen; Anne Tybjærg-Hansen; Ruth Frikke Schmidt; Kari Kuulasmaa; Dajiang J. Liu; Markus Perola; Stefan Blankenberg; Veikko Salomaa; Satu Männistö; Philippe Amouyel; Dominique Arveiler; Jean Ferrieres; Martina Müller-Nu...; Marco Ferrario; Frank Kee; Cristen J. Willer; Nilesh Samani; Heribert Schunkert; Adam S. Butterworth; Joanna M. M. Howson; Gina M. Peloso; Nathan O. Stitziel; John Danesh; Sekar Kathiresan; Daniel J. Rader; ; ; ; Sarah Watson; Ellen M. Schmidt; Sebanti Sengupta; Stefan Gustafsson; Stavroula Kanoni; Andrea Ganna; Jin Chen; Martin L. Buchkovich; Samia Mora; Jacques S. Beckmann; Jennifer L. Bragg...; Hsing-Yi Chang; Ayşe Demirkan; Heleen M. Den Hertog; Ron Do; Louise A. Donnelly; Georg B. Ehret; Tõnu Esko; Mary F. Feitosa; Teresa Ferreira; Krista Fischer; Pierre Fontanillas; Ross M. Fraser; Daniel F. Freitag; Deepti Gurdasani; Kauko Heikkilä; Elina Hyppönen; Aaron Isaacs; Anne U. Jackson; Åsa Johansson; Toby Johnson; Marika Kaakinen; Johannes Kettunen; Marcus E. Kleber; Xiaohui Li; Jian’an Luan; Leo-Pekka Lyytikä...; Patrik K. E. Magn...; Massimo Mangino; Evelin Mihailov; May E. Montasser; Ilja M. Nolte; Jeffrey R. O’Connell; Cameron D. Palmer; Ann-Kristin Petersen; Serena Sanna; Richa Saxena; Susan K. Service; Sonia Shah; Dmitry Shungin; Carlo Sidore; Ci Song; Rona J. Strawbridge; Ida Surakka; Toshiko Tanaka; Tanya M. Teslovich; Gudmar Thorleifsson; Evita G. Van den ...; Benjamin F. Voight; Kelly A. Volcik; Lindsay L. Waite; Andrew Wong; Ying Wu; Weihua Zhang; Devin Absher; Gershim Asiki; Inês Barroso; Latonya F. Been; Jennifer L. Bolton; Lori L. Bonnycastle; Paolo Brambilla; Mary S. Burnett; Giancarlo Cesana; Maria Dimitriou; Alex S. F. Doney; Angela Döring; Paul Elliott; Stephen E. Epstein; Gudmundur Ingi Ey...; Bruna Gigante; Mark O. Goodarzi; Harald Grallert; Martha L. Gravito; Christopher J. Gr...; Göran Hallmans; Anna-Liisa Hartik...; Caroline Hayward; Dena Hernandez; Andrew A. Hicks; Hilma Holm; Yi-Jen Hung; Thomas Illig; Michelle R. Jones; Pontiano Kaleebu; John J. P. Kastelein; Kay-Tee Khaw; Eric Kim; Norman Klopp; Pirjo Komulainen; Meena Kumari; Claudia Langenberg; Terho Lehtimäki; Shih-Yi Lin; Jaana Lindström; Ruth J. F. Loos; François Mach; Wendy L. McArdle; Christa Meisinger; Braxton D. Mitchell; Gabrielle Müller; Ramaiah Nagaraja; Narisu Narisu; Tuomo V. M. Nieminen; Rebecca N. Nsubuga; Isleifur Olafsson; Ken K. Ong; Aarno Palotie; Theodore Papamarkou; Cristina Pomilla; Anneli Pouta; Muredach P. Reilly; Paul M. Ridker; Fernando Rivadeneira; Igor Rudan; Aimo Ruokonen; Hubert Scharnagl; Janet Seeley; Kaisa Silander; Alena Stancáková; Kathleen Stirrups; Amy J. Swift; Laurence Tiret; Andre G. Uitterli...; L. J. van Pelt; Sailaja Vedantam; Nicholas Wainwright; Cisca Wijmenga; Sarah H. Wild; Gonneke Willemsen; Tom Wilsgaard; James F. Wilson; Elizabeth H. Young; Jing Hua Zhao; Linda S. Adair; Dominique Arveiler; Themistocles L. A...; Stefania Bandinelli; Franklyn Bennett; Murielle Bochud; Bernhard O. Boehm; Dorret I. Boomsma; Ingrid B. Borecki; Stefan R. Bornstein; Pascal Bovet; Michel Burnier; Harry Campbell; Aravinda Chakravarti; John C. Chambers; Yii-Der Ida Chen; Francis S. Collins; Richard S. Cooper; George Dedoussis; Ulf de Faire; Alan B. Feranil; Luigi Ferrucci; Nelson B. Freimer; Christian Gieger; Leif C. Groop; Vilmundur Gudnason; Ulf Gyllensten; Anders Hamsten; Tamara B. Harris; Aroon Hingorani; Joel N. Hirschhorn; Albert Hofman; G. Kees Hovingh; Chao Agnes Hsiung; Steve E. Humphries; Steven C. Hunt; Kristian Hveem; Carlos Iribarren; Marjo-Riitta Järv...; Antti Jula; Mika Kähönen; Jaakko Kaprio; Antero Kesäniemi; Mika Kivimaki; Jaspal S. Kooner; Peter J. Koudstaal; Ronald M. Krauss; Diana Kuh; Johanna Kuusisto; Kirsten O. Kyvik; Markku Laakso; Timo A. Lakka; Lars Lind; Cecilia M. Lindgren; Nicholas G. Martin; Winfried März; Mark I. McCarthy; Colin A. McKenzie; Pierre Meneton; Andres Metspalu; Leena Moilanen; Andrew D. Morris; Patricia B. Munroe; Inger Njølstad; Nancy L. Pedersen; Chris Power; Peter P. Pramstaller; Jackie F. Price; Bruce M. Psaty; Thomas Quertermous; Rainer Rauramaa; Veikko Salomaa; Dharambir K. Sang...; Jouko Saramies; Peter E. H. Schwarz; Wayne H.-H. Sheu; Alan R. Shuldiner; Agneta Siegbahn; Tim D. Spector; Kari Stefansson; David P. Strachan; Bamidele O. Tayo; Elena Tremoli; Jaakko Tuomilehto; Matti Uusitupa; Cornelia M. van D...; Peter Vollenweider; Lars Wallentin; Nicholas J. Wareham; John B. Whitfield; Bruce H. R. Wolff...; Jose M. Ordovas; Eric Boerwinkle; Colin N. A. Palmer; Unnur Thorsteinsd...; Daniel I. Chasman; Jerome I. Rotter; Paul W. Franks; Samuli Riatti; L. Adrienne Cupples; Manjinder S. Sandhu; Stephen S. Rich; Michael Boehnke; Panos Deloukas; Karen L. Mohlke; Erik Ingelsson; Dongfeng Gu; Robert Roberts; Hugh Watkins; Stefan Blankenberg; Robert Clarke; Rory Collins; Bong-Jo Kim; Ruth McPherson; Markku S. Nieminen; Christopher O'Don...; Stefan Schreiber; Agneta Siegbahn; Pierre A. Zalloua
• Keywords: Scavenger Receptor; Scavenger

A scavenger that protects the heart Coronary disease is a tale of two forms plasma cholesterol. In contrast to well-established effects “bad” cholesterol (LDL-C), role “good” (HDL-C) mysterious. Elevated HDL-C correlates with lower risk disease, yet drugs raise levels do not reduce risk. Zanoni et al. found some people exceptionally high carry rare sequence variant in gene encoding major receptor, receptor BI. This destroys receptor's ability take up HDL-C. Interestingly, this have higher despite having Science , issue p. 1166