Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals
Male
0301 basic medicine
570
Retroelements
*Gene Expression Regulation
*Fertilization
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
610
Protein-Restricted
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biochemistry
Gly
Molecular Genetics
Mice
03 medical and health sciences
Testis
Diet, Protein-Restricted
Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
UMCCTS funding
Translational Medical Research
Molecular Biology
Epididymis
2. Zero hunger
Cell Biology
RNA, Transfer, Gly
Spermatozoa
Diet
Transfer
*Sperm Maturation
Cellular and Molecular Physiology
Sperm Maturation
MicroRNAs
Blastocyst
Gene Expression Regulation
Fertilization
RNA
Developmental Biology
DOI:
10.1126/science.aad6780
Publication Date:
2016-01-01T03:33:48Z
AUTHORS (20)
ABSTRACT
Offspring affected by sperm small RNAs
Paternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests the involvement of epigenetic pathways, the mechanisms remains unclear. Two studies now show that altered paternal diet affects the level of small RNAs in mouse sperm. Chen
et al.
injected sperm transfer RNA (tRNA) fragments from males that had been kept on a high-fat diet into normal oocytes. The progeny displayed metabolic disorders and concomitant alteration of genes in metabolic pathways. Sharma
et al.
observed the biogenesis and function of small tRNA-derived fragments during sperm maturation. Further understanding of the mechanisms by which progeny are affected by parental exposure may affect human diseases such as diet-induced metabolic disorders.
Science
, this issue p.
397
, p.
391
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