A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

• DOI: 10.1126/science.aad6872
• Publication Date: 2016-10-06T18:13:31Z
• Authors: Yingfei Wang; Ran An; George K. Umanah; Hyejin Park; Kalyani Nambiar; Stephen M. Eacker; BongWoo Kim; Lei Bao; Maged M. Harraz; Calvin Chang; Rong Chen; Jennifer E. Wang; Tae-In Kam; Jun Seop Jeong; Zhi Xie; Stewart Neifert; Jiang Qian; Shaida A. Andrabi; Seth Blackshaw; Heng Zhu; Hongjun Song; Guo-li Ming; Valina L. Dawson; Ted M. Dawson
• Keywords: Nuclease; Fragmentation; Apoptosis-inducing factor

DNA damage-activated nuclease identified Cells that experience stresses and accumulate excessive damage to undergo cell death mediated by a nuclear enzyme known as PARP-1. During this process, apoptosis-inducing factor (AIF) translocates the nucleus activates one or more nucleases cleave DNA. Wang et al. found macrophage migration inhibitory (MIF) is an AIF-associated endonuclease contributes PARP-1-induced fragmentation (see Perspective Jonas). In mouse neurons in culture, loss of MIF protected from caused stimulation. Targeting could thus provide therapeutic strategy against diseases which PARP-1 activation excessive. Science , issue p. 82 ; see also 36