The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

• DOI: 10.1126/science.aae0065
• Publication Date: 2016-05-27T04:14:15Z
• Authors: Dong Fang; Haiyun Gan; Jeong-Heon Lee; Jing Han; Zhiquan Wang; Scott M. Riester; Long Jin; Jianji Chen; Hui Zhou; Jinglong Wang; Honglian Zhang; Na Yang; Elizabeth W. Bradley; Thai H. Ho; Brian P. Rubin; Julia A. Bridge; Stephen N. Thibodeau; Tamas Ordog; Yue Chen; Andre J. van Wijnen; Andre M. Oliveira; Rui-Ming Xu; Jennifer J. Weste...; Zhiguo Zhang
• Keywords: Epigenome; Histone Methylation; Epigenomics; Histone code

A cancer-promoting histone protein Mutations in the chromatin H3 are found a number of pediatric cancers. The lysine-36–to–methionine (K36M) “oncohistone” mutation is seen almost all chondroblastomas. Fang et al. show that K36M mutant histones inhibit normal methylation this same residue wild-type histones. They do so by interfering with enzymes normally methylate residue. altered patterns alter expression known cancer-related genes and impart characteristics to chondrocyte cells. Science , issue p. 1344