Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

• DOI: 10.1126/science.aaf0683
• Publication Date: 2017-03-10T02:05:22Z
• Authors: Alice O. Kamphorst; Andreas Wieland; Tahseen Nasti; Shu Yang; Ruan Zhang; Daniel L. Barber; Bogumila T. Konie...; Candace Z. Daugherty; Lydia Koenig; Ke Yu; Gabriel L. Sica; Arlene H. Sharpe; Gordon J. Freeman; Bruce R. Blazar; Laurence A. Turka; Taofeek K. Owonikoko; Rathi N. Pillai; Suresh S. Ramalingam; Koichi Araki; Rafi Ahmed
• Keywords: 0301 basic medicine; Lung Neoplasms; Programmed Cell Death 1 Receptor; CD8-Positive T-Lymphocytes; Lymphocytic Choriomeningitis; 3. Good health; Mice; 03 medical and health sciences; CD28 Antigens; Carcinoma, Non-Small-Cell Lung; B7-1 Antigen; Animals; Humans; Immunotherapy; Gene Deletion; Metabolic Networks and Pathways

Immunotherapeutic PD-1–targeted therapies require CD28 to promote cancer cell killing.