An anatomic transcriptional atlas of human glioblastoma

• DOI: 10.1126/science.aaf2666
• Publication Date: 2018-05-10T18:10:45Z
• Authors: Ralph B. Puchalski; Nameeta Shah; Jeremy Miller; Rachel Dalley; Steve R. Nomura; Jae-Guen Yoon; Kimberly A. Smith; Michael Lankerovich; Darren Bertagnolli; Kris Bickley; Andrew F. Boe; Krissy Brouner; Stephanie Butler; Shiella Caldejon; Mike Chapin; Suvro Datta; Nick Dee; Tsega Desta; Tim Dolbeare; Nadezhda Dotson; Amanda Ebbert; David Feng; Xu Feng; Michael Fisher; Garrett Gee; Jeff Goldy; Lindsey Gourley; Benjamin W. Gregor; Guangyu Gu; Nika Hejazinia; John Hohmann; Parvinder Hothi; Robert Howard; Kevin Joines; Ali Kriedberg; Leonard Kuan; Chris Lau; Felix Lee; Hwahyung Lee; Tracy Lemon; Fuhui Long; Naveed Mastan; Erika Mott; Chantal Murthy; Kiet Ngo; Eric Olson; Melissa Reding; Zack Riley; David Rosen; David Sandman; Nadiya Shapovalova; Clifford R. Slaug...; Andrew Sodt; Graham Stockdale; Aaron Szafer; Wayne Wakeman; Paul E. Wohnoutka; Steven J. White; Don Marsh; Robert C. Rostomily; Lydia Ng; Chinh Dang; Allan Jones; Bart Keogh; Haley R. Gittleman; Jill S. Barnholtz...; Patrick J. Cimino; Megha S. Uppin; C. Dirk Keene; Farrokh R. Farrokhi; Justin D. Lathia; Michael E. Berens; Antonio Iavarone; Amy Bernard; Ed Lein; John W. Phillips; Steven W. Rostad; Charles Cobbs; Michael J. Hawrylycz; Greg D. Foltz
• Keywords: Brain tumor; Brain atlas; Pathogenesis; Human Protein Atlas

Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, their relationships to histologic features routinely used for diagnosis unclear. We present the Ivy Atlas, anatomically based transcriptional atlas of human glioblastoma aligns individual with genomic alterations gene expression patterns, thus assigning information most important morphologic hallmarks tumor. its clinical database freely accessible online data resources will serve as valuable platform future investigations pathogenesis, diagnosis, treatment.