A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens

• DOI: 10.1126/science.aaf3552
• Publication Date: 2016-09-22T18:38:11Z
• Authors: Kavita J. Rangan; Virginia A. Pedicord; Yen-Chih Wang; Byungchul Kim; Yun Lu; Shai Shaham; Daniel Mucida; Howard C. Hang
• Keywords: Pathogenesis; Enterococcus faecium

The intestinal microbiome modulates host susceptibility to enteric pathogens, but the specific protective factors and mechanisms of individual bacterial species are not fully characterized. We show that secreted antigen A (SagA) from Enterococcus faecium is sufficient protect Caenorhabditis elegans against Salmonella pathogenesis by promoting pathogen tolerance. NlpC/p60 peptidoglycan hydrolase activity SagA required generates muramyl-peptide fragments C. in a tol-1-dependent manner. can also be heterologously expressed improve probiotics mice. Our study highlights how bacteria modify microbial-associated molecular patterns enhance