Self-renewal of a purified Tie2 + hematopoietic stem cell population relies on mitochondrial clearance

• DOI: 10.1126/science.aaf5530
• Publication Date: 2016-10-14T03:15:47Z
• Authors: Kyoko Ito; Raphaël Turcotte; Jinhua Cui; Samuel E. Zimmerman; Sandra Pinho; Toshihide Mizoguchi; Fumio Arai; Judith M. Runnels; Clemens Alt; Julie Teruya-Feld...; Jessica C. Mar; Rajat Singh; Toshio Suda; Charles P. Lin; Paul S. Frenette; Keisuke Ito
• Keywords: Multidisciplinary; 571; Ubiquitin-Protein Ligases; Fatty Acids; Green Fluorescent Proteins; Peroxisome Proliferator-Activated Receptors; Mitophagy; Cell Separation; Hematopoietic Stem Cells; Receptor, TIE-2; Hematopoiesis; Mitochondria; Mice, Inbred C57BL; Mice; 1000 General; Animals; Cell Self Renewal; Single-Cell Analysis; Oxidation-Reduction; Metabolic Networks and Pathways

Purified hematopoietic stem cells reveal that mitophagy plays a key role in their expansion.