Lactobacillus reuteri induces gut intraepithelial CD4 + CD8αα + T cells

• DOI: 10.1126/science.aah5825
• Publication Date: 2017-08-04T00:50:21Z
• Authors: Luisa Cervantes-B...; Jiani N. Chai; Ma. Diarey Tianero; Blanda Di Luccia; Philip P. Ahern; Joseph Merriman; Victor S. Cortez; Michael G. Caparon; Mohamed S. Donia; Susan Gilfillan; Marina Cella; Jeffrey I. Gordon; Chyi-Song Hsieh; Marco Colonna
• Keywords: Lactobacillus reuteri

Tolerogenic T cells need probiotics CD4 + CD8αα double-positive intraepithelial lymphocytes (DP IELs) are a recently discovered class of intestinal believed to take part in variety immune responses, including oral tolerance. These absent germ-free mice, but the mechanisms driving their development unclear. Cervantes-Barragan et al. found that particular species probiotic bacteria, Lactobacillus reuteri , induces DP IELs. This does not occur by stimulating system directly. Instead, L. generates specific derivative dietary tryptophan promotes differentiation IEL precursors. findings underscore delicate interplay between benign diet, and gut health. Science this issue p. 806