Induction of CD4 T cell memory by local cellular collectivity

• DOI: 10.1126/science.aaj1853
• Publication Date: 2018-06-14T18:10:41Z
• Authors: Michal Polonsky; Jacob Rimer; Amos Kern-Perets; Irina Zaretsky; Stav Miller; Chamutal Bornstein; Eyal David; Naama Meira Kopelman; Gil Stelzer; Ziv Porat; Benjamin Chain; Nir Friedman
• Keywords: Expansion; CD4-Positive T-Lymphocytes; 0301 basic medicine; Generation; Activation; Gene Expression; Expression; Mice, Transgenic; Mice; 03 medical and health sciences; Signaling Lymphocytic Activation Molecule Family; Animals; CD8(+) Effector; Computer Simulation; L-Selectin; Science & Technology; Interleukin-6; Sequence Analysis, RNA; Immunity; Models, Immunological; Quorum Sensing; Cell Differentiation; CD4 Lymphocyte Count; 3. Good health; Multidisciplinary Sciences; Mice, Inbred C57BL; Differentiation; Science & Technology - Other Topics; Interleukin-2; Lymphocyte Division; Infection; Specification; Immunologic Memory

Modeling memory differentiation in T cells

The balance between effector and central memory T cells shifts toward the latter as the number of T cells participating in immune responses increases. Polonsky et al. determined the mechanisms by which T cell quorum sensing affects memory differentiation by using live-cell imaging to track cell proliferation and differentiation. They found that the rate of memory CD4 + T cell differentiation is determined by cell number. This rate substantially increases above a threshold number of locally interacting cells. Mathematical modeling suggests that the number of initially seeded cells and the number of cell divisions are not critical. Instead, the instantaneous number of interacting cells continuously modulates the differentiation rate. This is partly fueled by increased sensitivity to the cytokines interleukin-2 (IL-2) and IL-6, independent of any effects on cell proliferation.

Science , this issue p. eaaj1853