Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

• DOI: 10.1126/science.aal4365
• Publication Date: 2017-03-31T00:52:17Z
• Authors: Susana V. Bardina; Paul Bunduc; Shashank Tripathi; James Duehr; Justin J. Frere; Julia A. Brown; Raffael Nachbagauer; Gregory A. Foster; David Krysztof; Domenico Tortorella; Susan L. Stramer; Adolfo García-Sastre; Florian Krammer; Jean K. Lim
• Keywords: Zika Virus; Viremia; Flavivirus; Antibody-dependent enhancement; Antibody titer

One antibody for all and antibodies one Antibodies against related flavi-viruses such as dengue (DENV) West Nile (WNV) can cross-react with Zika virus (ZIKV) could thereby increase disease severity. Bardina et al. tested whether DENV WNV from humans, or even yellow fever vaccination, enhance ZIKV infection. In a mouse model, low titers of enhanced viremia, especially in the spinal cord testes, whereas high remained protective. Generally, were less disease-enhancing than antibodies, and, macaques, vaccination had very little effect. Science , this issue p. 175