CX3CR1 + mononuclear phagocytes control immunity to intestinal fungi

• DOI: 10.1126/science.aao1503
• Publication Date: 2018-01-16T22:40:52Z
• Authors: Irina Leonardi; Xin Li; Alexa Semon; Dalin Li; Itai Doron; Gregory Putzel; Agnieszka Bar; Daniel Prieto; Maria Rescigno; Dermot P. B. McGo...; Jesus Pla; Iliyan D. Iliev
• Keywords: Mycobiota; CX3CR1; Posaconazole

Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis inflammatory disease. Nonetheless, mechanisms governing immunity to gut fungal communities (mycobiota) remain unknown. We identified CX3CR1+ mononuclear phagocytes (MNPs) as being essential for initiation innate adaptive responses intestinal fungi. MNPs express antifungal receptors activate a Syk-dependent manner. Genetic ablation mice led changes severe colitis that was rescued by treatment. In Crohn's disease patients, missense mutation gene encoding CX3CR1 found be associated with impaired responses. These results unravel role mediating interactions between mycobiota at steady state during