Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

• DOI: 10.1126/science.aao5774
• Publication Date: 2018-03-08T19:05:34Z
• Authors: Liping Zhao; Feng Zhang; Xiaoying Ding; Guojun Wu; Yan Y. Lam; Xuejiao Wang; Huaqing Fu; Xinhe Xue; Chunhua Lu; Jilin Ma; Lihua Yu; Chengmei Xu; Zhongying Ren; Ying Xu; Songmei Xu; Hongli Shen; Xiuli Zhu; Yu Shi; Qingyun Shen; Weiping Dong; Rui Liu; Yunxia Ling; Yue Zeng; Xingpeng Wang; Qianpeng Zhang; Jing Wang; Linghua Wang; Yanqiu Wu; Benhua Zeng; Hong Wei; Menghui Zhang; Yongde Peng; Chenhong Zhang
• Keywords: Prebiotic

The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together fecal shotgun metagenomics, to show that select group SCFA-producing strains was promoted by dietary fibers most other potential producers were either diminished or unchanged patients T2DM. When the fiber-promoted present greater diversity abundance, participants had better improvement hemoglobin A1c levels, partly increased glucagon-like peptide-1 production. Promotion these positive responders metabolically detrimental compounds such as indole hydrogen sulfide. Targeted restoration may novel ecological approach for managing