Variation in theAvrSr35gene determinesSr35resistance against wheat stem rust race Ug99

• DOI: 10.1126/science.aao7294
• Publication Date: 2017-12-21T20:21:35Z
• Authors: Andres Salcedo; William Rutter; Shichen Wang; Alina Akhunova; Stephen Bolus; Shiaoman Chao; Nickolas Anderson; Monica Fernandez ...; Matthew Rouse; Les Szabo; Robert L. Bowden; Jorge Dubcovsky; Eduard Akhunov
• Keywords: Stem rust; Variation (astronomy)

Puccinia graminis f. sp. tritici (Pgt) causes wheat stem rust, a devastating fungal disease. The Sr35 resistance gene confers immunity against this pathogen's most virulent races, including Ug99. We used comparative whole-genome sequencing of chemically mutagenized and natural Pgt isolates to identify named AvrSr35 that is required for avirulence. encodes secreted protein capable interacting with triggering the immune response. show origin on associated nonfunctionalization by insertion mobile element. discovery provides new tool surveillance, identification host susceptibility targets, characterization molecular determinants in wheat.