Detection and localization of surgically resectable cancers with a multi-analyte blood test

• DOI: 10.1126/science.aar3247
• Publication Date: 2018-01-18T19:00:40Z
• Authors: Joshua D. Cohen; Lu Li; Yuxuan Wang; Christopher Thoburn; Bahman Afsari; Ludmila Danilova; Christopher Douville; Ammar A. Javed; Fay Wong; Austin Mattox; Ralph H. Hruban; Christopher L. Wo...; Michael G. Goggins; Marco Dal Molin; Tian-Li Wang; Richard Roden; Alison P. Klein; Janine Ptak; Lisa Dobbyn; Joy Schaefer; Natalie Silliman; Maria Popoli; Joshua T. Vogelstein; James D. Browne; Robert E. Schoen; Randall E. Brand; Jeanne Tie; Peter Gibbs; Hui-Li Wong; Aaron S. Mansfield; Jin Jen; Samir M. Hanash; Massimo Falconi; Peter J. Allen; Shibin Zhou; Chetan Bettegowda; Luis A. Diaz; Cristian Tomasetti; Kenneth W. Kinzler; Bert Vogelstein; Anne Marie Lennon; Nickolas Papadopo...
• Keywords: Blood test; Stomach cancer

Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common types through assessment of the levels circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, 1005 patients with nonmetastatic, clinically detected cancers ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive median 70% types. The sensitivities ranged from 69 98% for five (ovary, esophagus) which there are no screening available average-risk individuals. specificity was greater than 99%: only 7 812 healthy controls scored positive. In addition, localized small number anatomic sites 83% patients.