Triggered recruitment of ESCRT machinery promotes endolysosomal repair

DNA-Binding Proteins 0301 basic medicine 03 medical and health sciences Endosomal Sorting Complexes Required for Transport Cell Line, Tumor Calcium-Binding Proteins Humans Cell Cycle Proteins Endosomes 14. Life underwater Lysosomes HeLa Cells Transcription Factors
DOI: 10.1126/science.aar5078 Publication Date: 2018-04-05T20:58:44Z
ABSTRACT
A quick fix for leaky endosomes Cells internalize diverse material through various forms of endocytosis into an extensive endolysosomal network. Protecting the integrity of endolysosomal membranes in both physiological and pathophysiological contexts is critical to cell health. Skowyra et al. describe a role for the ESCRT (endosomal sorting complex required for transport) machinery on endolysosomal organelles during membrane repair (see the Perspective by Gutierrez and Carlton). The ESCRTs act as first responders to repair limited membrane damage and thereby restore compartmental integrity and function. This ESCRT activity is distinct from organelle disposal pathways. These findings will be important in understanding cellular responses to invading pathogens and potentially disruptive proinflammatory particulates. Science , this issue p. eaar5078 ; see also p. 33
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