Triggered recruitment of ESCRT machinery promotes endolysosomal repair

• DOI: 10.1126/science.aar5078
• Publication Date: 2018-04-05T20:58:44Z
• Authors: Michael L. Skowyra; Paul H. Schlesinger; Teresa V. Naismith; Phyllis I. Hanson
• Keywords: DNA-Binding Proteins; 0301 basic medicine; 03 medical and health sciences; Endosomal Sorting Complexes Required for Transport; Cell Line, Tumor; Calcium-Binding Proteins; Humans; Cell Cycle Proteins; Endosomes; 14. Life underwater; Lysosomes; HeLa Cells; Transcription Factors

A quick fix for leaky endosomes

Cells internalize diverse material through various forms of endocytosis into an extensive endolysosomal network. Protecting the integrity of endolysosomal membranes in both physiological and pathophysiological contexts is critical to cell health. Skowyra et al. describe a role for the ESCRT (endosomal sorting complex required for transport) machinery on endolysosomal organelles during membrane repair (see the Perspective by Gutierrez and Carlton). The ESCRTs act as first responders to repair limited membrane damage and thereby restore compartmental integrity and function. This ESCRT activity is distinct from organelle disposal pathways. These findings will be important in understanding cellular responses to invading pathogens and potentially disruptive proinflammatory particulates.

Science , this issue p. eaar5078 ; see also p. 33