Triggered recruitment of ESCRT machinery promotes endolysosomal repair
DNA-Binding Proteins
0301 basic medicine
03 medical and health sciences
Endosomal Sorting Complexes Required for Transport
Cell Line, Tumor
Calcium-Binding Proteins
Humans
Cell Cycle Proteins
Endosomes
14. Life underwater
Lysosomes
HeLa Cells
Transcription Factors
DOI:
10.1126/science.aar5078
Publication Date:
2018-04-05T20:58:44Z
AUTHORS (4)
ABSTRACT
A quick fix for leaky endosomes
Cells internalize diverse material through various forms of endocytosis into an extensive endolysosomal network. Protecting the integrity of endolysosomal membranes in both physiological and pathophysiological contexts is critical to cell health. Skowyra
et al.
describe a role for the ESCRT (endosomal sorting complex required for transport) machinery on endolysosomal organelles during membrane repair (see the Perspective by Gutierrez and Carlton). The ESCRTs act as first responders to repair limited membrane damage and thereby restore compartmental integrity and function. This ESCRT activity is distinct from organelle disposal pathways. These findings will be important in understanding cellular responses to invading pathogens and potentially disruptive proinflammatory particulates.
Science
, this issue p.
eaar5078
; see also p.
33
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