Beyond PARP—POLθ as an anticancer target
0301 basic medicine
DNA End-Joining Repair
Genes, BRCA1
Antineoplastic Agents
DNA-Directed DNA Polymerase
Poly(ADP-ribose) Polymerase Inhibitors
DNA Repair-Deficiency Disorders
3. Good health
03 medical and health sciences
Neoplasms
Humans
DNA Breaks, Double-Stranded
Molecular Targeted Therapy
Poly(ADP-ribose) Polymerases
Homologous Recombination
DNA Polymerase theta
DOI:
10.1126/science.aar5149
Publication Date:
2018-03-15T19:50:46Z
AUTHORS (2)
ABSTRACT
Targeting cancers dependent on DNA polymerase θ has considerable clinical potential
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