High-fructose corn syrup enhances intestinal tumor growth in mice

• DOI: 10.1126/science.aat8515
• Publication Date: 2019-03-21T23:15:16Z
• Authors: Marcus D. Goncalves; Changyuan Lu; Jordan Tutnauer; Travis E. Hartman; Seo-Kyoung Hwang; Charles J Murphy; Chantal Pauli; Roxanne Morris; Sam Taylor; Kaitlyn Bosch; Sukjin Yang; Yumei Wang; Justin Van Riper; H Carl Lekaye; Jatin Roper; Young Kim; Qiuying Chen; Steven S. Gross; Kyu Y. Rhee; Lewis C. Cantley; Jihye Yun
• Keywords: High-fructose corn syrup; Corn syrup

Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated obesity and an increased risk colorectal cancer. Whether HFCS contributes directly to tumorigenesis unclear. We investigated the effects daily oral administration in adenomatous polyposis coli (APC) mutant mice, which are predisposed develop intestinal tumors. The HFCS-treated mice showed a substantial increase tumor size grade absence metabolic syndrome. concentrations fructose glucose lumen serum, respectively, tumors transported both sugars. Within tumors, was converted fructose-1-phosphate, leading activation glycolysis synthesis fatty acids that support growth. These mouse studies hypothesis combination dietary fructose, even at moderate dose, can enhance tumorigenesis.