Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

• DOI: 10.1126/science.aau0964
• Publication Date: 2019-03-14T23:44:28Z
• Authors: Svetoslav Chakarov; Hwee Ying Lim; Leonard Tan; Sheau Yng Lim; Peter See; Josephine Lum; Xiao-Meng Zhang; Shihui Foo; Satoshi Nakamizo; Kaibo Duan; Wan Ting Kong; Rebecca Gentek; Akhila Balachander; Daniel Carbajo; Camille Bleriot; Benoit Malleret; John Kit Chung Tam; Sonia Baig; Muhammad Shabeer; Sue-Anne Ee Shiow...; Andreas Schlitzer; Anis Larbi; Thomas Marichal; Bernard Malissen; Jinmiao Chen; Michael Poidinger; Kenji Kabashima; Marc Bajenoff; Lai Guan Ng; Veronique Angeli; Florent Ginhoux
• Keywords: EXPRESSION; 570; INDUCED PULMONARY-FIBROSIS; FATE; CX3C Chemokine Receptor 1; 610; Organic Anion Transporters; DENDRITIC CELLS; [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity; Monocytes; Mice; 03 medical and health sciences; REVEALS; Animals; Antigens, Ly; Cell Lineage; Lung; RESIDENT CARDIAC MACROPHAGES; Glycoproteins; 0303 health sciences; Science & Technology; FETAL MONOCYTES; IDENTIFICATION; RECEPTOR; Sequence Analysis, RNA; Macrophages; Myocardium; Histocompatibility Antigens Class II; Membrane Transport Proteins; Dermis; Fibrosis; Multidisciplinary Sciences; Mice, Inbred C57BL; Disease Models, Animal; Science & Technology - Other Topics; LYVE-1-POSITIVE MACROPHAGES; Single-Cell Analysis; Transcriptome

Tissue macrophages have a split personality

Resident tissue macrophages (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and tissue homeostasis. Chakarov et al. used single-cell RNA sequencing and fate-mapping of murine lung RTMs to interrogate RTM-subset heterogeneity, interrelationships, and ontogeny (see the Perspective by Mildner and Yona). In addition to alveolar macrophages, they identified two different interstitial macrophage populations. One population mostly abutted nerve fibers; the other population preferentially localized near blood vessels and appeared to support vessel integrity and inhibit inflammatory cell infiltration into tissues.

Science , this issue p. eaau0964 ; see also p. 1154