The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein

• DOI: 10.1126/science.aav0778
• Publication Date: 2019-04-25T23:10:45Z
• Authors: Chao Qi; Simona Sorrentino; Ohad Medalia; Volodymyr M. Korkhov
• Keywords: ADCY10

The architecture of a signaling hub Adenylyl cyclases (ACs) respond to variety inputs generate the molecule cyclic adenosine monophosphate. ACs are regulated by G proteins, which activated upstream receptors. Qi et al. determined structure bovine membrane AC9 bound an protein αs subunit cryo–electron microscopy at 3.4-angstrom resolution. provides full AC9, including helical domain that connects transmembrane and catalytic domains. model reveals how domains interact regulate enzymatic activity, suggesting mechanism self-inhibition. Science , this issue p. 389