Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

• DOI: 10.1126/science.aav9776
• Publication Date: 2019-04-04T23:13:45Z
• Authors: Silas Maniatis; Tarmo Äijö; Sanja Vickovic; Catherine Braine; Kristy Kang; Annelie Mollbrink; Delphine Fagegaltier; Žaneta Andrusivová; Sami Saarenpää; Gonzalo Saiz-Castro; Miguel Cuevas; Aaron Watters; Joakim Lundeberg; Richard Bonneau; Hemali Phatnani
• Keywords: Motor Neurons; 0301 basic medicine; 0303 health sciences; Gene Expression Profiling; Amyotrophic Lateral Sclerosis; Gene Expression; Disease Models, Animal; Mice; 03 medical and health sciences; Spatio-Temporal Analysis; Spinal Cord; Astrocytes; Postmortem Changes; Nerve Degeneration; Animals; Humans; Microglia; Muscle, Skeletal; Transcriptome; Neuroglia

Spatiotemporal gene expression in ALS Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that affects nerve cells the brain and spinal cord. It has proven difficult to identify early stages of where it spreads within body. Maniatis et al. used RNA sequencing define transcriptomic changes over course different regions cord mouse model postmortem human From expression, they identified disease-associated pathways established key steps degeneration observed ALS. Science , this issue p. 89