BAF restricts cGAS on nuclear DNA to prevent innate immune activation
Cell Nucleus
0301 basic medicine
2. Zero hunger
0303 health sciences
Nuclear Envelope
DNA
Nucleotidyltransferases
Immunity, Innate
3. Good health
DNA-Binding Proteins
03 medical and health sciences
Gene Knockdown Techniques
Humans
HeLa Cells
DOI:
10.1126/science.aaw6421
Publication Date:
2020-08-18T00:34:13Z
AUTHORS (8)
ABSTRACT
A loose BAF puts its foot on the cGAS
A signaling pathway in vertebrates called cGAS-STING detects the presence of intracellular DNA as a surrogate for both cellular damage and viral infection. At the same time, sensing of self-DNA must be suppressed to prevent the development of autoimmune responses. Guey
et al.
identify barrier-to-autointegration factor 1 (BAF) as a protein that intrinsically competes with the cGAS component of this pathway for binding to genomic self-DNA. When there is a breakdown in nuclear compartmentalization, cytosolic cGAS enzymatic activity is prevented because of BAF. This work suggests that the regulation of DNA detection by the innate immune system relies on more complex mechanisms than simple physical separation alone.
Science
, this issue p.
823
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