A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

• DOI: 10.1126/science.aay3638
• Publication Date: 2021-01-07T20:31:44Z
• Authors: Christina Krienke; Laura Kolb; Elif Diken; Michael Streuber; Sarah Kirchhoff; Thomas Bukur; Özlem Akilli-Öztürk; Lena M. Kranz; Hendrik Berger; Jutta Petschenka; Mustafa Diken; Sebastian Kreiter; Nir Yogev; Ari Waisman; Katalin Karikó; Özlem Türeci; Ugur Sahin
• Keywords: Encephalomyelitis

The ability to control autoreactive T cells without inducing systemic immune suppression is the major goal for treatment of autoimmune diseases. key challenge safe and efficient delivery pharmaceutically well-defined antigens in a noninflammatory context. Here, we show that nanoparticle-formulated 1 methylpseudouridine-modified messenger RNA (m1Ψ mRNA) coding disease-related autoantigens results antigen presentation on splenic CD11c+ antigen-presenting absence costimulatory signals. In several mouse models multiple sclerosis, disease suppressed by with such m1Ψ mRNA. effect associated reduction effector development regulatory cell (Treg cell) populations. Notably, these Treg execute strong bystander immunosuppression thus improve induced cognate noncognate autoantigens.