A broadly protective antibody that targets the flavivirus NS1 protein

• DOI: 10.1126/science.abb9425
• Publication Date: 2021-01-07T20:31:44Z
• Authors: Naphak Modhiran; Hao Song; Lidong Liu; Cheryl Bletchly; Lou Brillault; Alberto A. Amarilla; Xiaoying Xu; Jianxun Qi; Yan Chai; Stacey T. M. Cheung; Renee Traves; Yin Xiang Setoh; Summa Bibby; Connor A. P. Scott; Morgan E. Freney; Natalee D. Newton; Alexander A. Khro...; Keith J. Chappell; David A. Muller; Katryn J. Stacey; Michael J. Landsberg; Yi Shi; George F. Gao; Paul R. Young; Daniel Watterson
• Keywords: Flavivirus; Viremia; Zika Virus; Antibody-dependent enhancement

Two antibodies against flaviviruses Flaviviruses are a group of RNA viruses that include the human pathogens dengue virus, Zika and West Nile virus. The envelope protein (E) on virus surface has been target vaccine development, but problems have arisen with E, leading to enhanced infection. Now, Modhiran et al. Biering describe two different bind flavivirus NS1 prevent it from disrupting epithelial cells, which is associated severe disease. Both cross-react multiple proteins. reduce viremia increase survival in mouse models papers structures bound an antibody, give insight into protective mechanism. Science , this issue p. 190 194