Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
2019-20 coronavirus outbreak
DOI:
10.1126/science.abd4570
Publication Date:
2020-09-24T23:13:31Z
AUTHORS (748)
ABSTRACT
The genetics underlying severe COVID-19 immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody dampens IFN response prevent damage from pathogen-induced inflammation. Two studies now examine likelihood affects risk of coronavirus disease 2019 (COVID-19) through components this (see Perspective by Beck Aksentijevich). Q. Zhang et al. used a candidate gene approach identified patients with who have mutations in genes involved regulation type I III immunity. They found enrichment these conclude may determine clinical course infection. Bastard individuals high titers neutralizing autoantibodies against IFN-α2 IFN-ω about 10% pneumonia. These were not either infected people asymptomatic or had milder phenotype healthy individuals. Together, identify means which at highest life-threatening identified. Science , issue p. eabd4570 eabd4585 ; see also 404
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