Designed proteins assemble antibodies into modular nanocages

• DOI: 10.1126/science.abd9994
• Publication Date: 2021-04-01T19:05:47Z
• Authors: Robby Divine; Ha V. Dang; George Ueda; Jorge A. Fallas; Ivan Vulovic; William Sheffler; Shally Saini; Yan Ting Zhao; Infencia Xavier Raj; Peter A. Morawski; Madeleine F. Jenn...; Leah J. Homad; Yu-Hsin Wan; Marti R. Tooley; Franziska Seeger; Ali Etemadi; Mitchell L. Fahning; James Lazarovits; Alex Roederer; Alexandra C. Walls; Lance Stewart; Mohammadali Mazloomi; Neil P. King; Daniel J. Campbell; Andrew T. McGuire; Leonidas Stamatatos; Hannele Ruohola-B...; Julie Mathieu; David Veesler; David Baker
• Keywords: Nanocages

Integrating form and function for design Antibodies are broadly used in therapies as research tools because they can be generated against a wide range of targets. Efficacy often increased by clustering antibodies multivalent assemblies. Divine et al. designed antibody nanocages from two components: One is an antibody-binding homo-oligomic protein the other itself. Computationally proteins drive assembly architectures, allowing control symmetry valency. The display enhances antibody-dependent signaling, displaying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike effectively neutralize pseudovirus. Science , this issue p. eabd9994