Striatal dopamine mediates hallucination-like perception in mice

• DOI: 10.1126/science.abf4740
• Publication Date: 2021-04-01T19:05:47Z
• Authors: K. Schmack; M. Bosc; T. Ott; J. F. Sturgill; A. Kepecs
• Keywords: Animal model

How to model hallucinations in mice There has not been enough progress our understanding of the basic mechanisms underlying psychosis. Studying psychotic disorders animal models is difficult because diagnosis relies on self-reported symptoms that can only be assessed humans. Schmack et al. developed a paradigm probe and rigorously measure experimentally controlled rodents (see Perspective by Matamales). Using dopamine-sensor measurements circuit pharmacological manipulations, they demonstrated brain link between excessive dopamine hallucination-like experience. This could potentially useful as translational common described various psychiatric disorders. It may also help development new therapeutic approaches based anatomically selective modulation function. Science , this issue p. eabf4740 ; see 33