Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity

• DOI: 10.1126/science.abf8683
• Publication Date: 2021-07-01T19:08:34Z
• Authors: Parsa Akbari; Ankit Gilani; Olukayode Sosina; Jack A. Kosmicki; Lori Khrimian; Yi-Ya Fang; Trikaldarshi Persaud; Victor Garcia; Dylan Sun; Alexander Li; Joelle Mbatchou; Adam E. Locke; Christian Benner; Niek Verweij; Nan Lin; Sakib Hossain; Kevin Agostinucci; Jonathan V. Pascale; Ercument Dirice; Michael Dunn; ; ; William E. Kraus; Svati H. Shah; Yii-Der I. Chen; Jerome I. Rotter; Daniel J. Rader; Olle Melander; Christopher D. Still; Tooraj Mirshahi; David J. Carey; Jaime Berumen-Campos; Pablo Kuri-Morales; Jesus Alegre-Díaz; Jason M. Torres; Jonathan R. Emberson; Rory Collins; Suganthi Balasubr...; Alicia Hawes; Marcus Jones; Brian Zambrowicz; Andrew J. Murphy; Charles Paulding; Giovanni Coppola; John D. Overton; Jeffrey G. Reid; Alan R. Shuldiner; Michael Cantor; Hyun M. Kang; Goncalo R. Abecasis; Katia Karalis; Aris N. Economides; Jonathan Marchini; George D. Yancopo...; Mark W. Sleeman; Judith Altarejos; Giusy Della Gatta; Roberto Tapia-Conyer; Michal L. Schwart...; Aris Baras; Manuel A. R. Ferr...; Luca A. Lotta
• Keywords: Exome

How genes affect human obesity Obesity is linked to many diseases, including diabetes, cancer, and heart disease. There thus great interest in understanding how predispose individuals to, or protect from, obesity. Akbari et al. sequenced more than 600,000 exomes from the United Kingdom, States, Mexico identified 16 rare coding variants (see Perspective by Yeo O'Rahilly). Some of alleles associated with body mass index (BMI) were brain-expressed G protein–coupled receptors. One variant allele was found Mexican populations at low frequency lower BMI. Deletion this gene mice resulted a resistance weight gain, suggesting that provides an avenue study for prevention treatment Science , abf8683, issue p. eabf8683 ; see also abh3556, 30