Microfluidic-like fabrication of metal ion–cured bioadhesives by mussels

0301 basic medicine Mytilus edulis Iron Secretory Vesicles Microfluidics Proteins Biological Transport Vanadium Spectrum Analysis, Raman Dihydroxyphenylalanine 03 medical and health sciences Adhesives Animals
DOI: 10.1126/science.abi9702 Publication Date: 2021-10-16T02:02:59Z
ABSTRACT
Mussel mooring made mighty by metals Mussels produce an exceptional proteinaceous adhesive so they can withstand waves and currents. Metal ions bound to modified tyrosine residues play an important role in reinforcing the adhesive. Priemel et al . brought together a variety of spectroscopy and microscopy techniques to study the cellular mechanisms involved in adhesive fabrication in mussels (see the Perspective by Wilker). They found that metal ion–rich vesicles are secreted alongside vesicles containing the adhesive protein and mix in a microfluidic-like process within interconnected microchannels found in the lateral duct of the mussel foot to create porous, adhesive plaque filaments. —MAF
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