Robust variation in infant gut microbiome assembly across a spectrum of lifestyles

• DOI: 10.1126/science.abj2972
• Publication Date: 2022-06-09T17:56:06Z
• Authors: Matthew R. Olm; Dylan Dahan; Matthew M. Carter; Bryan D. Merrill; Feiqiao B. Yu; Sunit Jain; Xiandong Meng; Surya Tripathi; Hannah Wastyk; Norma Neff; Susan Holmes; Erica D. Sonnenburg; Aashish R. Jha; Justin L. Sonnenburg
• Keywords: Gut microbiome; Variation (astronomy); Infant feeding; Out of africa

Infant microbiome assembly has been intensely studied in infants from industrialized nations, but little is known about this process nonindustrialized populations. We deeply sequenced infant stool samples the Hadza hunter-gatherers of Tanzania and analyzed them a global meta-analysis. microbiomes develop along lifestyle-associated trajectories, with more than 20% genomes detected gut representing novel species. Industrialized infants-even those who are breastfed-have characterized by paucity