mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

• DOI: 10.1126/science.abm0829
• Publication Date: 2021-10-15T03:06:19Z
• Authors: Rishi R. Goel; Mark M. Painter; Sokratis A. Apost...; Divij Mathew; Wenzhao Meng; Aaron M. Rosenfeld; Kendall A. Lundgreen; Arnold Reynaldi; David S. Khoury; Ajinkya Pattekar; Sigrid Gouma; Leticia Kuri-Cerv...; Philip Hicks; Sarah Dysinger; Amanda Hicks; Harsh Sharma; Sarah Herring; Scott Korte; Amy E. Baxter; Derek A. Oldridge; Josephine R. Giles; Madison E. Weirick; Christopher M. Mc...; Moses Awofolaju; Nicole Tanenbaum; Elizabeth M. Drapeau; Jeanette Dougherty; Sherea Long; Kurt D’Andrea; Jacob T. Hamilton; Maura McLaughlin; Justine C. Williams; Sharon Adamski; Oliva Kuthuru; ; Ian Frank; Michael R. Betts; Laura A. Vella; Alba Grifoni; Daniela Weiskopf; Alessandro Sette; Scott E. Hensley; Miles P. Davenport; Paul Bates; Eline T. Luning Prak; Allison R. Greenp...; E. John Wherry
• Keywords: Immunological memory

Immune memory after vaccination Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven highly effective at preventing COVID-19. However, the evolution of viral variants, and waning antibody levels over time, raise questions regarding longevity vaccine-induced immune protection. Goel et al . examined B T lymphocyte responses in individuals who received SARS-CoV-2 messenger RNA vaccines. They performed a 6-month longitudinal study never had infection compared with people recovered from SARS-CoV-2. Humoral cellular was observed vaccinated individuals, as were functional Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2) variants. Analysis cell activity suggested that robust may prevent hospitalization by limiting development disease. —PNK