Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging

• DOI: 10.1126/science.abn6583
• Publication Date: 2022-04-14T17:59:05Z
• Authors: Michele Gabriele; Hugo B. Brandão; Simon Grosse-Holz; Asmita Jha; Gina M. Dailey; Claudia Cattoglio; Tsung-Han S. Hsieh; Leonid Mirny; Christoph Zechner; Anders S. Hansen
• Keywords: CTCF; Live cell imaging; Dynamics

Animal genomes are folded into loops and topologically associating domains (TADs) by CTCF loop-extruding cohesins, but the live dynamics of loop formation stability remain unknown. Here, we directly visualized chromatin looping at